No proof of tumorigenicity was observed in male and female mice at codeine dietary doses around 400 mg/kg/working day (approximately equivalent to 45 periods the MRHD on the mg/m2 basis).

The drug is excreted generally within the urine, mainly as inactive metabolites and little amounts of free of charge and conjugated morphine. Negligible amounts of codeine and its metabolites are located in the feces.

Administration of codeine might be accompanied by histamine release and should be applied with warning in atopic children.

Promethazine is contraindicated in comatose states, and in people today recognised to generally be hypersensitive or to obtain experienced an idiosyncratic reaction to promethazine or to other phenothiazines.

Dextromethorphan is on the market in each prescription and nonprescription products. Check out the labels of your drugs to ensure that you usually are not getting more than one product that contains dextromethorphan.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers a lot less than six years of age. Concomitant administration of promethazine products with other respiratory depressants has an Affiliation with respiratory depression, and at times Demise, in pediatric patients. The Affiliation does in a roundabout way relate to individualized weight-based mostly dosing, which might normally allow Protected administration.

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A healthcare Skilled needs to be consulted in advance of having any drug, shifting any diet or commencing or discontinuing any course of treatment.

Particular scientific studies to test the action of your drug on parturition, lactation, and development from the animal neonate were not carried out, but a standard preliminary review in rats indicated no effect on these parameters.

It's not a whole listing of achievable side effects. If you notice other Unwanted side effects not outlined higher than, Get in touch with your doctor or pharmacist.

Propulsive peristaltic waves from the colon are lessened, when tone could be enhanced to The purpose of spasm leading to constipation. Other opioid-induced effects could consist of a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.

Procedure of Overdose Procedure of overdosage is pushed by the overall medical presentation, and is made up of discontinuation of Promethazine HCl and Codeine Phosphate Oral Answer along with institution of proper therapy. Give Key attention into the reestablishment of ample respiratory Trade via provision of the patent and protected airway as well as establishment of assisted or controlled ventilation.

This is simply not a whole listing of attainable Unwanted side effects. In case you notice other side effects not stated previously mentioned, Make contact with your medical professional or pharmacist.

The level of medicine that you choose to take depends on the strength in the medicine. Also, the number of doses you're taking every single day, enough time permitted involving doses, and also the length of time you take the Promethazine codeine syrup medicine depend on the clinical problem for which that you are using the medicine.